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KMID : 0358420080510030313
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Korean Journal of Obstetrics and Gynecology
2008 Volume.51 No. 3 p.313 ~ p.323
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The expression of annexin 1 and thymosin β4 in cervical cancer
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Lee Yu-Sun
Chung Hye-Won
Moon Hye-Sung
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Abstract
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Objective : The aim of this study was to compare the expression of annexin I and thymosin β4 in invasive cervical cancer including normal cervix and CIN.
Methods : In Ewha Womans University Mokdong Hospital, normal cervical tissues were obtained from healthy women (n=10), from patients with cervical intraepithelial neoplasia (CIN, n=10) and from patients with cervical cancer (n=33). The expressions of annexin I and thymosin β4 mRNA and protein were examined by quantitative competitive-PCR and by western blot analysis. The expressions of annexin I and thymosin β4 protein were measured by western blot analysis with thymosin β4 peptides non treated and treated SiHa cells.
Results : The expression of thymosin β4 mRNA and protein in cervical cancer were higher than that in normal cervix (p<0.05). The expression of annexin I mRNA and protein were higher than that in normal cervix and CIN (p<0.05). Thymosin β4 and annexin I mRNA expressions were not significantly correlated with cervical cancer stage, or size of the tumor (p>0.05). But thymosin β4 and annexin I protein expressions were increased according to the cancer stage. The expression of annexin I was slightly higher in thymosin β4 treated SiHa cells than that in nontreated SiHa cells.
Conclusion : Our results suggest that overexpression of thymosin β4 and annexin I may play roles in progression of invasive cervical cancer. Thymosin β4 upregulates expression of annexin I in invasive cervical cancer. Therefore, thymosin β4 and annexin I may be biological markers in detecting the progression of invasive cervical cancer, and their interaction is important in invasive cervical cancer.
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KEYWORD
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Annexin 1, Thymosin β4, Cervical cancer
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